Human Mitochondrial DNA Replication

Por Holt, Ian J., Reyes, Aurelio
Publicado em 2012

The road to rack and ruin: selecting deleterious mitochondrial DNA variants

Por Holt, Ian J., Speijer, Dave, Kirkwood, Thomas B. L.
Publicado em 2014

Prominent mitochondrial DNA recombination intermediates in human heart muscle

Por Kajander, Olli A., Karhunen, Pekka J., Holt, Ian J., Jacobs, Howard T.
Publicado em 2001

A robust assay to measure DNA topology-dependent protein binding affinity

Por Litwin, Tamara R., Solà, Maria, Holt, Ian J., Neuman, Keir C.
Publicado no Nucleic Acids Res (2015)

Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts

Por Reyes, Aurelio, Kazak, Lawrence, Wood, Stuart R., Yasukawa, Takehiro, Jacobs, Howard T., Holt, Ian J.
Publicado em 2013

Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them

Por Poulton, Joanna, Chiaratti, Marcos R., Meirelles, Flávio V., Kennedy, Stephen, Wells, Dagan, Holt, Ian J.
Publicado em 2010

MSH2 ATPase Domain Mutation Affects CTG•CAG Repeat Instability in Transgenic Mice

Por Tomé, Stéphanie, Holt, Ian, Edelmann, Winfried, Morris, Glenn E., Munnich, Arnold, Pearson, Christopher E., Gourdon, Geneviève
Publicado em 2009

Mitochondrial Transcription Terminator Family Members mTTF and mTerf5 Have Opposing Roles in Coordination of mtDNA Synthesis

Por Jõers, Priit, Lewis, Samantha C., Fukuoh, Atsushi, Parhiala, Mikael, Ellilä, Simo, Holt, Ian J., Jacobs, Howard T.
Publicado em 2013

Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand

Por Yasukawa, Takehiro, Reyes, Aurelio, Cluett, Tricia J, Yang, Ming-Yao, Bowmaker, Mark, Jacobs, Howard T, Holt, Ian J
Publicado em 2006

A Cryptic Targeting Signal Creates a Mitochondrial FEN1 Isoform with Tailed R-Loop Binding Properties

Por Kazak, Lawrence, Reyes, Aurelio, He, Jiuya, Wood, Stuart R., Brea-Calvo, Gloria, Holen, Torgeir T., Holt, Ian J.
Publicado em 2013

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA

Por Bailey, Laura J., Cluett, Tricia J., Reyes, Aurelio, Prolla, Tom A., Poulton, Joanna, Leeuwenburgh, Christiaan, Holt, Ian J.
Publicado em 2009

An Upstream Open Reading Frame and the Context of the Two AUG Codons Affect the Abundance of Mitochondrial and Nuclear RNase H1

Por Suzuki, Yutaka, Holmes, J. Bradley, Cerritelli, Susana M., Sakhuja, Kiran, Minczuk, Michal, Holt, Ian J., Crouch, Robert J.
Publicado em 2010

The conserved translocase Tim17 prevents mitochondrial DNA loss

Por Iacovino, Michelina, Granycome, Caroline, Sembongi, Hiroshi, Bokori-Brown, Monika, Butow, Ronald A., Holt, Ian J., Bateman, Joseph M.
Publicado em 2009

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

Por Pohjoismäki, Jaakko L. O., Wanrooij, Sjoerd, Hyvärinen, Anne K., Goffart, Steffi, Holt, Ian J., Spelbrink, Johannes N., Jacobs, Howard T.
Publicado em 2006

Nesprins: Tissue-Specific Expression of Epsilon and Other Short Isoforms

Por Duong, Nguyen Thuy, Morris, Glenn E., Lam, Le Thanh, Zhang, Qiuping, Sewry, Caroline A., Shanahan, Catherine M., Holt, Ian
Publicado em 2014

Muscleblind-Like Proteins : Similarities and Differences in Normal and Myotonic Dystrophy Muscle

Por Holt, Ian, Jacquemin, Virginie, Fardaei, Majid, Sewry, Caroline A., Butler-Browne, Gillian S., Furling, Denis, Brook, J. David, Morris, Glenn E.
Publicado em 2009

Expanded CUG Repeats Dysregulate RNA Splicing by Altering the Stoichiometry of the Muscleblind 1 Complex

Por Paul, Sharan, Dansithong, Warunee, Jog, Sonali P., Holt, Ian, Mittal, Saloni, Brook, J. David, Morris, Glenn E., Comai, Lucio, Reddy, Sita
Publicado em 2011

Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody

Por Holt, Ian, Duong, Nguyen Thuy, Zhang, Qiuping, Lam, Le Thanh, Sewry, Caroline A., Mamchaoui, Kamel, Shanahan, Catherine M., Morris, Glenn E.
Publicado no BMC Cell Biol (2016)

Systematic Segregation to Mutant Mitochondrial DNA and Accompanying Loss of Mitochondrial DNA in Human NT2 Teratocarcinoma Cybrids

Por Turner, Carrie J., Granycome, Caroline, Hurst, Rachel, Pohler, Elizabeth, Juhola, M. Katariina, Juhola, Martti I., Jacobs, Howard T., Sutherland, Lesley, Holt, Ian J.
Publicado em 2005

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

Por Sharma, Nilesh K., Reyes, Aurelio, Green, Paula, Caron, Matthieu J., Bonini, Marcelo G., Gordon, Donna M., Holt, Ian J., Santos, Janine Hertzog
Publicado em 2012