Muscleblind-Like Proteins : Similarities and Differences in Normal and Myotonic Dystrophy Muscle

In myotonic dystrophy, muscleblind-like protein 1 (MBNL1) protein binds specifically to expanded CUG or CCUG repeats, which accumulate as discrete nuclear foci, and this is thought to prevent its function in the regulation of alternative splicing of pre-mRNAs. There is strong evidence for the role o...

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Autors principals: Holt, Ian, Jacquemin, Virginie, Fardaei, Majid, Sewry, Caroline A., Butler-Browne, Gillian S., Furling, Denis, Brook, J. David, Morris, Glenn E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2009
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631334/
https://ncbi.nlm.nih.gov/pubmed/19095965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080520
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