Large CTG Repeats Trigger p16-Dependent Premature Senescence in Myotonic Dystrophy Type 1 Muscle Precursor Cells

A CTG repeat amplification is responsible for the dominantly inherited neuromuscular disorder, myotonic dystrophy type 1 (DM1), which is characterized by progressive muscle wasting and weakness. The expanded (CTG)n tract not only alters the myogenic differentiation of the DM1 muscle precursor cells...

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Detalhes bibliográficos
Main Authors: Bigot, Anne, Klein, Arnaud F., Gasnier, Erwan, Jacquemin, Virginie, Ravassard, Philippe, Butler-Browne, Gillian, Mouly, Vincent, Furling, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671374/
https://ncbi.nlm.nih.gov/pubmed/19246640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080560
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