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The road to rack and ruin: selecting deleterious mitochondrial DNA variants

Mitochondria constitute the major energy-producing compartment of the eukaryotic cell. These organelles contain many molecules of DNA that contribute only a handful of proteins required for energy production. Mutations in the DNA of mitochondria were identified as a cause of human disease a quarter...

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Bibliografiska uppgifter
Huvudupphovsmän: Holt, Ian J., Speijer, Dave, Kirkwood, Thomas B. L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Royal Society 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032523/
https://ncbi.nlm.nih.gov/pubmed/24864317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2013.0451
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