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Is PrP the road to ruin?

One feature of neurodegenerative disorders is the accumulation of β-sheet-rich misfolded proteins, but how these proteins trigger cell death is not clear. Resenberger and coworkers report in this issue that the cellular prion protein can mediate neurotoxic signalling of various β-sheet-rich conforme...

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Detalhes bibliográficos
Main Authors: Barton, Kelly A, Caughey, Byron
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098489/
https://ncbi.nlm.nih.gov/pubmed/21593729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.129
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