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PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection
Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP(C)) influences PrP(C) misfolding into the disease-associated isoform, PrP(res), as well as prion propagation and infectivity. GPI proteins are found in cholesterol- and sphingolipid-rich membrane regions called rafts. Exchanging...
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| Veröffentlicht in: | J Virol |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5215353/ https://ncbi.nlm.nih.gov/pubmed/27847358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01686-16 |
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