PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection

Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP(C)) influences PrP(C) misfolding into the disease-associated isoform, PrP(res), as well as prion propagation and infectivity. GPI proteins are found in cholesterol- and sphingolipid-rich membrane regions called rafts. Exchanging...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Marshall, Karen E., Hughson, Andrew, Vascellari, Sarah, Priola, Suzette A., Sakudo, Akikazu, Onodera, Takashi, Baron, Gerald S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Prions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215353/
https://ncbi.nlm.nih.gov/pubmed/27847358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01686-16
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