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Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.

Transmissible spongiform encephalopathies are characterized by spongiosis, astrocytosis and accumulation of PrPSc, an isoform of the normal host protein PrPC. The exact cell types responsible for agent propagation and pathogenesis are still uncertain. To determine the possible role of astrocytes, we...

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Dettagli Bibliografici
Autori principali: Raeber, A J, Race, R E, Brandner, S, Priola, S A, Sailer, A, Bessen, R A, Mucke, L, Manson, J, Aguzzi, A, Oldstone, M B, Weissmann, C, Chesebro, B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326289/
https://ncbi.nlm.nih.gov/pubmed/9321385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.20.6057
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