Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.

Transmissible spongiform encephalopathies are characterized by spongiosis, astrocytosis and accumulation of PrPSc, an isoform of the normal host protein PrPC. The exact cell types responsible for agent propagation and pathogenesis are still uncertain. To determine the possible role of astrocytes, we...

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Bibliographische Detailangaben
Hauptverfasser: Raeber, A J, Race, R E, Brandner, S, Priola, S A, Sailer, A, Bessen, R A, Mucke, L, Manson, J, Aguzzi, A, Oldstone, M B, Weissmann, C, Chesebro, B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326289/
https://ncbi.nlm.nih.gov/pubmed/9321385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.20.6057
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