Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.

Transmissible spongiform encephalopathies are characterized by spongiosis, astrocytosis and accumulation of PrPSc, an isoform of the normal host protein PrPC. The exact cell types responsible for agent propagation and pathogenesis are still uncertain. To determine the possible role of astrocytes, we...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Raeber, A J, Race, R E, Brandner, S, Priola, S A, Sailer, A, Bessen, R A, Mucke, L, Manson, J, Aguzzi, A, Oldstone, M B, Weissmann, C, Chesebro, B
Format: Artigo
Langue:Inglês
Publié: 1997
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326289/
https://ncbi.nlm.nih.gov/pubmed/9321385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.20.6057
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires