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Normal host prion protein (PrP(C)) is required for scrapie spread within the central nervous system

Mice devoid of PrP(C) (Prnp(o/o)) are resistant to scrapie and do not allow propagation of the infectious agent (prion). PrP(C)-expressing neuroectodermal tissue grafted into Prnp(o/o) brains but not the surrounding tissue consistently exhibits scrapie-specific pathology and allows prion replication...

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Detalhes bibliográficos
Main Authors: Brandner, Sebastian, Raeber, Alex, Sailer, Andreas, Blättler, Thomas, Fischer, Marek, Weissmann, Charles, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1996
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24061/
https://ncbi.nlm.nih.gov/pubmed/8917559
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