Normal host prion protein (PrP(C)) is required for scrapie spread within the central nervous system
Mice devoid of PrP(C) (Prnp(o/o)) are resistant to scrapie and do not allow propagation of the infectious agent (prion). PrP(C)-expressing neuroectodermal tissue grafted into Prnp(o/o) brains but not the surrounding tissue consistently exhibits scrapie-specific pathology and allows prion replication...
Sábháilte in:
| Foilsithe in: | Proc Natl Acad Sci U S A |
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| Príomhchruthaitheoirí: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe / Cruthaithe: |
National Academy of Sciences
1996
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| Ábhair: | |
| Rochtain ar líne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24061/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8917559/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.23.13148 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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