Normal host prion protein (PrP(C)) is required for scrapie spread within the central nervous system

Mice devoid of PrP(C) (Prnp(o/o)) are resistant to scrapie and do not allow propagation of the infectious agent (prion). PrP(C)-expressing neuroectodermal tissue grafted into Prnp(o/o) brains but not the surrounding tissue consistently exhibits scrapie-specific pathology and allows prion replication...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Brandner, Sebastian, Raeber, Alex, Sailer, Andreas, Blättler, Thomas, Fischer, Marek, Weissmann, Charles, Aguzzi, Adriano
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24061/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8917559/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.23.13148
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