Systematic Segregation to Mutant Mitochondrial DNA and Accompanying Loss of Mitochondrial DNA in Human NT2 Teratocarcinoma Cybrids

In this study a well-characterized pathological mutation at nucleotide position 3243 of human mitochondrial DNA was introduced into human ρ(0) teratocarcinoma (NT2) cells. In cloned and mixed populations of NT2 cells heteroplasmic for the mutation, mitotic segregation toward increasing levels of mut...

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Main Authors: Turner, Carrie J., Granycome, Caroline, Hurst, Rachel, Pohler, Elizabeth, Juhola, M. Katariina, Juhola, Martti I., Jacobs, Howard T., Sutherland, Lesley, Holt, Ian J.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2005
Teme:
Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449769/
https://ncbi.nlm.nih.gov/pubmed/15944344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.043653
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