Targeting cancer with kinase inhibitors

by Gross, Stefan, Rahal, Rami, Stransky, Nicolas, Lengauer, Christoph, Hoeflich, Klaus P.
Published in J Clin Invest (2015)

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells

by Arias-Romero, Luis E., Villamar-Cruz, Olga, Huang, Min, Hoeflich, Klaus P., Chernoff, Jonathan
Published 2013

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway

by Radu, Maria, Lyle, Karen, Hoeflich, Klaus P., Villamar-Cruz, Olga, Koeppen, Hartmut, Chernoff, Jonathan
Published in Mol Cell Biol (2015)

FDG-PET is a good biomarker of both early response and acquired resistance in BRAF(V600) mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973

by Baudy, Andreas R, Dogan, Taner, Flores-Mercado, Judith E, Hoeflich, Klaus P, Su, Fei, van Bruggen, Nicholas, Williams, Simon-Peter
Published 2012

Combined Targeting of BRAF and CRAF or BRAF and PI3K Effector Pathways Is Required for Efficacy in NRAS Mutant Tumors

by Jaiswal, Bijay S., Janakiraman, Vasantharajan, Kljavin, Noelyn M., Eastham-Anderson, Jeffrey, Cupp, James E., Liang, Yuxin, Davis, David P., Hoeflich, Klaus P., Seshagiri, Somasekar
Published 2009

p21-activated kinase 1: PAK'ed with potential

by Ong, Christy C., Jubb, Adrian M., Zhou, Wei, Haverty, Peter M., Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Hoeflich, Klaus P.
Published 2011

The PI3K inhibitor taselisib overcomes letrozole resistance in a breast cancer model expressing aromatase

by Hoeflich, Klaus P., Guan, Jane, Edgar, Kyle A., O'Brien, Carol, Savage, Heidi, Wilson, Timothy R., Neve, Richard M., Friedman, Lori S., Wallin, Jeffrey J.
Published in Genes Cancer (2016)

Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition

by Kirkpatrick, Donald S., Bustos, Daisy J., Dogan, Taner, Chan, Jocelyn, Phu, Lilian, Young, Amy, Friedman, Lori S., Belvin, Marcia, Song, Qinghua, Bakalarski, Corey E., Hoeflich, Klaus P.
Published 2013

<it>p</it>HUSH: a single vector system for conditional gene expression

by Eby Mike, Murray Lesley J, Gogineni Alvin, Gu Zhenyu, Peng Li, Hoeflich Klaus P, Gray Daniel C, Kljavin Noelyn, Seshagiri Somasekar, Cole Mary J, Davis David P
Published 2007-09-01

pHUSH: a single vector system for conditional gene expression

by Gray, Daniel C, Hoeflich, Klaus P, Peng, Li, Gu, Zhenyu, Gogineni, Alvin, Murray, Lesley J, Eby, Mike, Kljavin, Noelyn, Seshagiri, Somasekar, Cole, Mary J, Davis, David P
Published 2007

Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

by Gnad, Florian, Young, Amy, Zhou, Wei, Lyle, Karen, Ong, Christy C., Stokes, Matthew P., Silva, Jeffrey C., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Minden, Audrey, Hoeflich, Klaus P.
Published 2013

Group I Paks as therapeutic targets in NF2-deficient meningioma

by Chow, Hoi-Yee, Dong, Biao, Duron, Sergio G., Campbell, David A., Ong, Christy C., Hoeflich, Klaus P., Chang, Long-Sheng, Welling, D. Bradley, Yang, Zeng-jie, Chernoff, Jonathan
Published in Oncotarget (2015)

Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle

by Dogan, Taner, Gnad, Florian, Chan, Jocelyn, Phu, Lilian, Young, Amy, Chen, Mark J., Doll, Sophia, Stokes, Matthew P., Belvin, Marcia, Friedman, Lori S., Kirkpatrick, Donald S., Hoeflich, Klaus P., Hatzivassiliou, Georgia
Published in J Biol Chem (2017)

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

by Rudolph, Joachim, Aliagas, Ignacio, Crawford, James J., Mathieu, Simon, Lee, Wendy, Chao, Qi, Dong, Ping, Rouge, Lionel, Wang, Weiru, Heise, Christopher, Murray, Lesley J., La, Hank, Liu, Yanzhou, Manning, Gerard, Diederich, François, Hoeflich, Klaus P.
Published in ACS Med Chem Lett (2015)

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

by Ong, Christy C., Jubb, Adrian M., Haverty, Peter M., Zhou, Wei, Tran, Victoria, Truong, Tom, Turley, Helen, O'Brien, Tom, Vucic, Domagoj, Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Blackwood, Elizabeth M., Koeppen, Hartmut, Hoeflich, Klaus P.
Published 2011

Multiplexed gene expression profiling identifies the FGFR4 pathway as a novel biomarker in intrahepatic cholangiocarcinoma

by Yoo, Changhoon, Kang, Jihoon, Kim, Deokhoon, Kim, Kyu-Pyo, Ryoo, Baek-Yeol, Hong, Seung-Mo, Hwang, Jung Jin, Jeong, Seong-Yun, Hwang, Shin, Kim, Ki-Hun, Lee, Young-Joo, Hoeflich, Klaus P., Schmidt-Kittler, Oleg, Miller, Stephen, Choi, Eun Kyung
Published in Oncotarget (2017)

Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes

by Wallin, Jeffrey J., Guan, Jane, Edgar, Kyle A., Zhou, Wei, Francis, Ross, Torres, Anthony C., Haverty, Peter M., Eastham-Anderson, Jeffrey, Arena, Sabrina, Bardelli, Alberto, Griffin, Sue, Goodall, John E., Grimshaw, Kyla M., Hoeflich, Klaus P., Torrance, Christopher, Belvin, Marcia, Friedman, Lori S.
Published 2012

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

by Degtyarev, Michael, De Mazière, Ann, Orr, Christine, Lin, Jie, Lee, Brian B., Tien, Janet Y., Prior, Wei W., van Dijk, Suzanne, Wu, Hong, Gray, Daniel C., Davis, David P., Stern, Howard M., Murray, Lesley J., Hoeflich, Klaus P., Klumperman, Judith, Friedman, Lori S., Lin, Kui
Published 2008

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

by Zhou, Wei, Jubb, Adrian M, Lyle, Karen, Xiao, Qian, Ong, Christy C, Desai, Rupal, Fu, Ling, Gnad, Florian, Song, Qinghua, Haverty, Peter M, Aust, Daniela, Grützmann, Robert, Romero, Mally, Totpal, Klara, Neve, Richard M, Yan, Yibing, Forrest, William F, Wang, Yulei, Raja, Rajiv, Pilarsky, Christian, de Jesus-Acosta, Ana, Belvin, Marcia, Friedman, Lori S, Merchant, Mark, Jaffee, Elizabeth M, Zheng, Lei, Koeppen, Hartmut, Hoeflich, Klaus P
Published in J Pathol (2014)

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK(a) Polar Moiety

by Ndubaku, Chudi O., Crawford, James J., Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M., Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E., Hoeflich, Klaus P., Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P., Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J., O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Published in ACS Med Chem Lett (2015)