Targeting cancer with kinase inhibitors

Autor Gross, Stefan, Rahal, Rami, Stransky, Nicolas, Lengauer, Christoph, Hoeflich, Klaus P.
Vydáno v J Clin Invest (2015)

Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells

Autor Arias-Romero, Luis E., Villamar-Cruz, Olga, Huang, Min, Hoeflich, Klaus P., Chernoff, Jonathan
Vydáno 2013

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway

Autor Radu, Maria, Lyle, Karen, Hoeflich, Klaus P., Villamar-Cruz, Olga, Koeppen, Hartmut, Chernoff, Jonathan
Vydáno v Mol Cell Biol (2015)

FDG-PET is a good biomarker of both early response and acquired resistance in BRAF(V600) mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973

Autor Baudy, Andreas R, Dogan, Taner, Flores-Mercado, Judith E, Hoeflich, Klaus P, Su, Fei, van Bruggen, Nicholas, Williams, Simon-Peter
Vydáno 2012

Combined Targeting of BRAF and CRAF or BRAF and PI3K Effector Pathways Is Required for Efficacy in NRAS Mutant Tumors

Autor Jaiswal, Bijay S., Janakiraman, Vasantharajan, Kljavin, Noelyn M., Eastham-Anderson, Jeffrey, Cupp, James E., Liang, Yuxin, Davis, David P., Hoeflich, Klaus P., Seshagiri, Somasekar
Vydáno 2009

p21-activated kinase 1: PAK'ed with potential

Autor Ong, Christy C., Jubb, Adrian M., Zhou, Wei, Haverty, Peter M., Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Hoeflich, Klaus P.
Vydáno 2011

The PI3K inhibitor taselisib overcomes letrozole resistance in a breast cancer model expressing aromatase

Autor Hoeflich, Klaus P., Guan, Jane, Edgar, Kyle A., O'Brien, Carol, Savage, Heidi, Wilson, Timothy R., Neve, Richard M., Friedman, Lori S., Wallin, Jeffrey J.
Vydáno v Genes Cancer (2016)

Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition

Autor Kirkpatrick, Donald S., Bustos, Daisy J., Dogan, Taner, Chan, Jocelyn, Phu, Lilian, Young, Amy, Friedman, Lori S., Belvin, Marcia, Song, Qinghua, Bakalarski, Corey E., Hoeflich, Klaus P.
Vydáno 2013

<it>p</it>HUSH: a single vector system for conditional gene expression

Autor Eby Mike, Murray Lesley J, Gogineni Alvin, Gu Zhenyu, Peng Li, Hoeflich Klaus P, Gray Daniel C, Kljavin Noelyn, Seshagiri Somasekar, Cole Mary J, Davis David P
Vydáno 2007-09-01

pHUSH: a single vector system for conditional gene expression

Autor Gray, Daniel C, Hoeflich, Klaus P, Peng, Li, Gu, Zhenyu, Gogineni, Alvin, Murray, Lesley J, Eby, Mike, Kljavin, Noelyn, Seshagiri, Somasekar, Cole, Mary J, Davis, David P
Vydáno 2007

Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

Autor Gnad, Florian, Young, Amy, Zhou, Wei, Lyle, Karen, Ong, Christy C., Stokes, Matthew P., Silva, Jeffrey C., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Minden, Audrey, Hoeflich, Klaus P.
Vydáno 2013

Group I Paks as therapeutic targets in NF2-deficient meningioma

Autor Chow, Hoi-Yee, Dong, Biao, Duron, Sergio G., Campbell, David A., Ong, Christy C., Hoeflich, Klaus P., Chang, Long-Sheng, Welling, D. Bradley, Yang, Zeng-jie, Chernoff, Jonathan
Vydáno v Oncotarget (2015)

Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle

Autor Dogan, Taner, Gnad, Florian, Chan, Jocelyn, Phu, Lilian, Young, Amy, Chen, Mark J., Doll, Sophia, Stokes, Matthew P., Belvin, Marcia, Friedman, Lori S., Kirkpatrick, Donald S., Hoeflich, Klaus P., Hatzivassiliou, Georgia
Vydáno v J Biol Chem (2017)

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

Autor Rudolph, Joachim, Aliagas, Ignacio, Crawford, James J., Mathieu, Simon, Lee, Wendy, Chao, Qi, Dong, Ping, Rouge, Lionel, Wang, Weiru, Heise, Christopher, Murray, Lesley J., La, Hank, Liu, Yanzhou, Manning, Gerard, Diederich, François, Hoeflich, Klaus P.
Vydáno v ACS Med Chem Lett (2015)

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

Autor Ong, Christy C., Jubb, Adrian M., Haverty, Peter M., Zhou, Wei, Tran, Victoria, Truong, Tom, Turley, Helen, O'Brien, Tom, Vucic, Domagoj, Harris, Adrian L., Belvin, Marcia, Friedman, Lori S., Blackwood, Elizabeth M., Koeppen, Hartmut, Hoeflich, Klaus P.
Vydáno 2011

Multiplexed gene expression profiling identifies the FGFR4 pathway as a novel biomarker in intrahepatic cholangiocarcinoma

Autor Yoo, Changhoon, Kang, Jihoon, Kim, Deokhoon, Kim, Kyu-Pyo, Ryoo, Baek-Yeol, Hong, Seung-Mo, Hwang, Jung Jin, Jeong, Seong-Yun, Hwang, Shin, Kim, Ki-Hun, Lee, Young-Joo, Hoeflich, Klaus P., Schmidt-Kittler, Oleg, Miller, Stephen, Choi, Eun Kyung
Vydáno v Oncotarget (2017)

Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes

Autor Wallin, Jeffrey J., Guan, Jane, Edgar, Kyle A., Zhou, Wei, Francis, Ross, Torres, Anthony C., Haverty, Peter M., Eastham-Anderson, Jeffrey, Arena, Sabrina, Bardelli, Alberto, Griffin, Sue, Goodall, John E., Grimshaw, Kyla M., Hoeflich, Klaus P., Torrance, Christopher, Belvin, Marcia, Friedman, Lori S.
Vydáno 2012

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Autor Degtyarev, Michael, De Mazière, Ann, Orr, Christine, Lin, Jie, Lee, Brian B., Tien, Janet Y., Prior, Wei W., van Dijk, Suzanne, Wu, Hong, Gray, Daniel C., Davis, David P., Stern, Howard M., Murray, Lesley J., Hoeflich, Klaus P., Klumperman, Judith, Friedman, Lori S., Lin, Kui
Vydáno 2008

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

Autor Zhou, Wei, Jubb, Adrian M, Lyle, Karen, Xiao, Qian, Ong, Christy C, Desai, Rupal, Fu, Ling, Gnad, Florian, Song, Qinghua, Haverty, Peter M, Aust, Daniela, Grützmann, Robert, Romero, Mally, Totpal, Klara, Neve, Richard M, Yan, Yibing, Forrest, William F, Wang, Yulei, Raja, Rajiv, Pilarsky, Christian, de Jesus-Acosta, Ana, Belvin, Marcia, Friedman, Lori S, Merchant, Mark, Jaffee, Elizabeth M, Zheng, Lei, Koeppen, Hartmut, Hoeflich, Klaus P
Vydáno v J Pathol (2014)

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK(a) Polar Moiety

Autor Ndubaku, Chudi O., Crawford, James J., Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M., Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E., Hoeflich, Klaus P., Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P., Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J., O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Vydáno v ACS Med Chem Lett (2015)