Engineering an Improved IgG4 Molecule with Reduced Disulfide Bond Heterogeneity and Increased Fab Domain Thermal Stability

Por Peters, Shirley J., Smales, C. Mark, Henry, Alistair J., Stephens, Paul E., West, Shauna, Humphreys, David P.
Publicado em 2012

Relative stabilities of IgG1 and IgG4 Fab domains: Influence of the light–heavy interchain disulfide bond architecture

Por Heads, James T, Adams, Ralph, D'Hooghe, Lena E, Page, Matt J T, Humphreys, David P, Popplewell, Andrew G, Lawson, Alastair D, Henry, Alistair J
Publicado em 2012

Conservation of Functional Sites on Interleukin-6 and Implications for Evolution of Signaling Complex Assembly and Therapeutic Intervention

Por Veverka, Vaclav, Baker, Terry, Redpath, Nicholas T., Carrington, Bruce, Muskett, Frederick W., Taylor, Richard J., Lawson, Alastair D. G., Henry, Alistair J., Carr, Mark D.
Publicado em 2012

High Resolution NMR-based Model for the Structure of a scFv-IL-1β Complex: POTENTIAL FOR NMR AS A KEY TOOL IN THERAPEUTIC ANTIBODY DESIGN AND DEVELOPMENT

Por Wilkinson, Ian C., Hall, Catherine J., Veverka, Vaclav, Shi, Jiye Y., Muskett, Frederick W., Stephens, Paul E., Taylor, Richard J., Henry, Alistair J., Carr, Mark D.
Publicado em 2009

Structure of the Tandem MA-3 Region of Pdcd4 Protein and Characterization of Its Interactions with eIF4A and eIF4G: MOLECULAR MECHANISMS OF A TUMOR SUPPRESSOR

Por Waters, Lorna C., Strong, Sarah L., Ferlemann, Eva, Oka, Ojore, Muskett, Frederick W., Veverka, Vaclav, Banerjee, Sreemoti, Schmedt, Thore, Henry, Alistair J., Klempnauer, Karl-Heinz, Carr, Mark D.
Publicado em 2011

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI

Por Dhaliwal, Balvinder, Yuan, Daopeng, Pang, Marie O. Y., Henry, Alistair J., Cain, Katharine, Oxbrow, Amanda, Fabiane, Stella M., Beavil, Andrew J., McDonnell, James M., Gould, Hannah J., Sutton, Brian J.
Publicado em 2012

Human immunoglobulin E flexes between acutely bent and extended conformations

Por Drinkwater, Nyssa, Cossins, Ben, Keeble, Anthony H, Wright, Michael, Cain, Katharine, Hailu, Hanna, Oxbrow, Amanda, Delgado, Jean, Shuttleworth, Lindsay K, Kao, Michael W-P, McDonnell, James M, Beavil, Andrew J, Henry, Alistair J, Sutton, Brian J
Publicado em 2014

Characterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATION

Por Veverka, Vaclav, Henry, Alistair J., Slocombe, Patrick M., Ventom, Andrew, Mulloy, Barbara, Muskett, Frederick W., Muzylak, Mariusz, Greenslade, Kevin, Moore, Adrian, Zhang, Li, Gong, Jianhua, Qian, Xueming, Paszty, Chris, Taylor, Richard J., Robinson, Martyn K., Carr, Mark D.
Publicado em 2009

Conformational Heterogeneity in Antibody-Protein Antigen Recognition: IMPLICATIONS FOR HIGH AFFINITY PROTEIN COMPLEX FORMATION

Por Addis, Philip W., Hall, Catherine J., Bruton, Shaun, Veverka, Vaclav, Wilkinson, Ian C., Muskett, Frederick W., Renshaw, Philip S., Prosser, Christine E., Carrington, Bruce, Lawson, Alastair D. G., Griffin, Robert, Taylor, Richard J., Waters, Lorna C., Henry, Alistair J., Carr, Mark D.
Publicado em 2014

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab

Por Davies, Anna M., Allan, Elizabeth G., Keeble, Anthony H., Delgado, Jean, Cossins, Benjamin P., Mitropoulou, Alkistis N., Pang, Marie O. Y., Ceska, Tom, Beavil, Andrew J., Craggs, Graham, Westwood, Marta, Henry, Alistair J., McDonnell, James M., Sutton, Brian J.
Publicado no J Biol Chem (2017)

Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors

Por Holdsworth, Gill, Slocombe, Patrick, Doyle, Carl, Sweeney, Bernadette, Veverka, Vaclav, Le Riche, Kelly, Franklin, Richard J., Compson, Joanne, Brookings, Daniel, Turner, James, Kennedy, Jeffery, Garlish, Rachael, Shi, Jiye, Newnham, Laura, McMillan, David, Muzylak, Mariusz, Carr, Mark D., Henry, Alistair J., Ceska, Thomas, Robinson, Martyn K.
Publicado em 2012

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

Por Cheng, Xiaoxiao, Veverka, Vaclav, Radhakrishnan, Anand, Waters, Lorna C., Muskett, Frederick W., Morgan, Sara H., Huo, Jiandong, Yu, Chao, Evans, Edward J., Leslie, Alasdair J., Griffiths, Meryn, Stubberfield, Colin, Griffin, Robert, Henry, Alistair J., Jansson, Andreas, Ladbury, John E., Ikemizu, Shinji, Carr, Mark D., Davis, Simon J.
Publicado em 2013