Conformational Heterogeneity in Antibody-Protein Antigen Recognition: IMPLICATIONS FOR HIGH AFFINITY PROTEIN COMPLEX FORMATION

Specific, high affinity protein-protein interactions lie at the heart of many essential biological processes, including the recognition of an apparently limitless range of foreign proteins by natural antibodies, which has been exploited to develop therapeutic antibodies. To mediate biological proces...

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Detalhes bibliográficos
Main Authors: Addis, Philip W., Hall, Catherine J., Bruton, Shaun, Veverka, Vaclav, Wilkinson, Ian C., Muskett, Frederick W., Renshaw, Philip S., Prosser, Christine E., Carrington, Bruce, Lawson, Alastair D. G., Griffin, Robert, Taylor, Richard J., Waters, Lorna C., Henry, Alistair J., Carr, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945379/
https://ncbi.nlm.nih.gov/pubmed/24436329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492215
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