Conformational Heterogeneity in Antibody-Protein Antigen Recognition: IMPLICATIONS FOR HIGH AFFINITY PROTEIN COMPLEX FORMATION

Specific, high affinity protein-protein interactions lie at the heart of many essential biological processes, including the recognition of an apparently limitless range of foreign proteins by natural antibodies, which has been exploited to develop therapeutic antibodies. To mediate biological proces...

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Hlavní autoři: Addis, Philip W., Hall, Catherine J., Bruton, Shaun, Veverka, Vaclav, Wilkinson, Ian C., Muskett, Frederick W., Renshaw, Philip S., Prosser, Christine E., Carrington, Bruce, Lawson, Alastair D. G., Griffin, Robert, Taylor, Richard J., Waters, Lorna C., Henry, Alistair J., Carr, Mark D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945379/
https://ncbi.nlm.nih.gov/pubmed/24436329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492215
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