Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins

Dickkopf (Dkk) family proteins are important regulators of Wnt signaling pathways, which play key roles in many essential biological processes. Here, we report the first detailed structural and dynamics study of a full-length mature Dkk protein (Dkk4, residues 19–224), including determination of the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Patel, Saleha, Barkell, Alice M., Gupta, Deepti, Strong, Sarah L., Bruton, Shaun, Muskett, Frederick W., Addis, Philip W., Renshaw, Philip S., Slocombe, Patrick M., Doyle, Carl, Clargo, Alison, Taylor, Richard J., Prosser, Christine E., Henry, Alistair J., Robinson, Martyn K., Waters, Lorna C., Holdsworth, Gill, Carr, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078440/
https://ncbi.nlm.nih.gov/pubmed/29925589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002918
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