Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins

Dickkopf (Dkk) family proteins are important regulators of Wnt signaling pathways, which play key roles in many essential biological processes. Here, we report the first detailed structural and dynamics study of a full-length mature Dkk protein (Dkk4, residues 19–224), including determination of the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Patel, Saleha, Barkell, Alice M., Gupta, Deepti, Strong, Sarah L., Bruton, Shaun, Muskett, Frederick W., Addis, Philip W., Renshaw, Philip S., Slocombe, Patrick M., Doyle, Carl, Clargo, Alison, Taylor, Richard J., Prosser, Christine E., Henry, Alistair J., Robinson, Martyn K., Waters, Lorna C., Holdsworth, Gill, Carr, Mark D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2018
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078440/
https://ncbi.nlm.nih.gov/pubmed/29925589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002918
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