Characterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATION

The secreted glycoprotein sclerostin has recently emerged as a key negative regulator of Wnt signaling in bone and has stimulated considerable interest as a potential target for therapeutics designed to treat conditions associated with low bone mass, such as osteoporosis. We have determined the stru...

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Autori principali: Veverka, Vaclav, Henry, Alistair J., Slocombe, Patrick M., Ventom, Andrew, Mulloy, Barbara, Muskett, Frederick W., Muzylak, Mariusz, Greenslade, Kevin, Moore, Adrian, Zhang, Li, Gong, Jianhua, Qian, Xueming, Paszty, Chris, Taylor, Richard J., Robinson, Martyn K., Carr, Mark D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667775/
https://ncbi.nlm.nih.gov/pubmed/19208630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807994200
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