Characterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATION

The secreted glycoprotein sclerostin has recently emerged as a key negative regulator of Wnt signaling in bone and has stimulated considerable interest as a potential target for therapeutics designed to treat conditions associated with low bone mass, such as osteoporosis. We have determined the stru...

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Hlavní autoři: Veverka, Vaclav, Henry, Alistair J., Slocombe, Patrick M., Ventom, Andrew, Mulloy, Barbara, Muskett, Frederick W., Muzylak, Mariusz, Greenslade, Kevin, Moore, Adrian, Zhang, Li, Gong, Jianhua, Qian, Xueming, Paszty, Chris, Taylor, Richard J., Robinson, Martyn K., Carr, Mark D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667775/
https://ncbi.nlm.nih.gov/pubmed/19208630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807994200
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