Human immunoglobulin E flexes between acutely bent and extended conformations

Crystallographic and solution studies have shown that IgE molecules are acutely bent in their Fc region. Crystal structures reveal the Cε2 domain pair folded back onto the Cε3-Cε4 domains, but is the molecule exclusively bent or can the Cε2 domains adopt extended conformations and even “flip” from o...

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Detalhes bibliográficos
Main Authors: Drinkwater, Nyssa, Cossins, Ben, Keeble, Anthony H, Wright, Michael, Cain, Katharine, Hailu, Hanna, Oxbrow, Amanda, Delgado, Jean, Shuttleworth, Lindsay K, Kao, Michael W-P, McDonnell, James M, Beavil, Andrew J, Henry, Alistair J, Sutton, Brian J
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977038/
https://ncbi.nlm.nih.gov/pubmed/24632569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2795
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