Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI

The role of IgE in allergic disease mechanisms is performed principally through its interactions with two receptors, FcεRI on mast cells and basophils, and CD23 (FcεRII) on B cells. The former mediates allergic hypersensitivity, the latter regulates IgE levels, and both receptors, also expressed on...

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Detalhes bibliográficos
Main Authors: Dhaliwal, Balvinder, Yuan, Daopeng, Pang, Marie O. Y., Henry, Alistair J., Cain, Katharine, Oxbrow, Amanda, Fabiane, Stella M., Beavil, Andrew J., McDonnell, James M., Gould, Hannah J., Sutton, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412039/
https://ncbi.nlm.nih.gov/pubmed/22802656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207278109
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