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Attenuation of IgE Affinity for FcεRI Radically Reduces the Allergic Response in Vitro and in Vivo
The high affinity of IgE for its receptor, FcεRI (K(a) ∼ 10(10) m(–1)), is responsible for the persistence of mast cell sensitization. Cross-linking of FcεRI-bound IgE by multivalent allergen leads to cellular activation and release of pro-inflammatory mediators responsible for the symptoms of aller...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662060/ https://ncbi.nlm.nih.gov/pubmed/18703499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804742200 |
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