Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcεRI

Of all the antibody classes, IgE displays a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor FcεRI. The structural basis for these key determinants of IgE’s ability to mediate allergic hypersensitivity is now revealed by the 3.4Å resolution crystal structure of...

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Detalhes bibliográficos
Main Authors: Holdom, M.D., Davies, A.M., Nettleship, J.E., Bagby, S.C., Dhaliwal, B., Girardi, E., Hunt, J., Gould, H.J., Beavil, A.J., McDonnell, J.M., Owens, R.J., Sutton, B.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357048/
https://ncbi.nlm.nih.gov/pubmed/21516097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2044
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