Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcεRI

Of all the antibody classes, IgE displays a uniquely slow dissociation rate from, and high affinity for, its cell surface receptor FcεRI. The structural basis for these key determinants of IgE’s ability to mediate allergic hypersensitivity is now revealed by the 3.4Å resolution crystal structure of...

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書誌詳細
主要な著者: Holdom, M.D., Davies, A.M., Nettleship, J.E., Bagby, S.C., Dhaliwal, B., Girardi, E., Hunt, J., Gould, H.J., Beavil, A.J., McDonnell, J.M., Owens, R.J., Sutton, B.J.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357048/
https://ncbi.nlm.nih.gov/pubmed/21516097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2044
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