Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-FcϵRI Interaction

IgE, the antibody that mediates allergic responses, acts as part of a self-regulating protein network. Its unique effector functions are controlled through interactions of its Fc region with two cellular receptors, FcϵRI on mast cells and basophils and CD23 on B cells. IgE cross-linked by allergen t...

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Main Authors: Borthakur, Susmita, Hibbert, Richard G., Pang, Marie O. Y., Yahya, Norhakim, Bax, Heather J., Kao, Michael W., Cooper, Alison M., Beavil, Andrew J., Sutton, Brian J., Gould, Hannah J., McDonnell, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438978/
https://ncbi.nlm.nih.gov/pubmed/22815482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.397059
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