A range of C∊3–C∊4 interdomain angles in IgE Fc accommodate binding to its receptor CD23

The antibody IgE plays a central role in allergic disease, functioning principally through two cell-surface receptors: Fc∊RI and CD23. Fc∊RI on mast cells and basophils mediates the immediate hypersensitivity response, whilst the interaction of IgE with CD23 on B cells regulates IgE production. Crys...

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Main Authors: Dhaliwal, Balvinder, Pang, Marie O. Y., Yuan, Daopeng, Beavil, Andrew J., Sutton, Brian J.
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2014
Teme:
Structural Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944690/
https://ncbi.nlm.nih.gov/pubmed/24598915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14003355
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