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A range of C∊3–C∊4 interdomain angles in IgE Fc accommodate binding to its receptor CD23
The antibody IgE plays a central role in allergic disease, functioning principally through two cell-surface receptors: Fc∊RI and CD23. Fc∊RI on mast cells and basophils mediates the immediate hypersensitivity response, whilst the interaction of IgE with CD23 on B cells regulates IgE production. Crys...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
International Union of Crystallography
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3944690/ https://ncbi.nlm.nih.gov/pubmed/24598915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14003355 |
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