Identifying bottlenecks in transient and stable production of recombinant monoclonal-antibody sequence variants in Chinese hamster ovary cells

Por Mason, Megan, Sweeney, Bernadette, Cain, Katharine, Stephens, Paul, Sharfstein, Susan T.
Publicado em 2012

Chromatin Function Modifying Elements in an Industrial Antibody Production Platform - Comparison of UCOE, MAR, STAR and cHS4 Elements

Por Saunders, Fay, Sweeney, Berni, Antoniou, Michael N., Stephens, Paul, Cain, Katharine
Publicado no PLoS One (2015)

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response

Por Chalmers, Fiona, van Lith, Marcel, Sweeney, Bernadette, Cain, Katharine, Bulleid, Neil J.
Publicado no Wellcome Open Res (2017)

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design

Por Stoyle, Chloe L., Stephens, Paul E., Humphreys, David P., Heywood, Sam, Cain, Katharine, Bulleid, Neil J.
Publicado no Biochem J (2017)

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI

Por Dhaliwal, Balvinder, Yuan, Daopeng, Pang, Marie O. Y., Henry, Alistair J., Cain, Katharine, Oxbrow, Amanda, Fabiane, Stella M., Beavil, Andrew J., McDonnell, James M., Gould, Hannah J., Sutton, Brian J.
Publicado em 2012

Human immunoglobulin E flexes between acutely bent and extended conformations

Por Drinkwater, Nyssa, Cossins, Ben, Keeble, Anthony H, Wright, Michael, Cain, Katharine, Hailu, Hanna, Oxbrow, Amanda, Delgado, Jean, Shuttleworth, Lindsay K, Kao, Michael W-P, McDonnell, James M, Beavil, Andrew J, Henry, Alistair J, Sutton, Brian J
Publicado em 2014

Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Por Stöppler, Daniel, Macpherson, Alex, Smith-Penzel, Susanne, Basse, Nicolas, Lecomte, Fabien, Deboves, Hervé, Taylor, Richard D., Norman, Tim, Porter, John, Waters, Lorna C., Westwood, Marta, Cossins, Ben, Cain, Katharine, White, James, Griffin, Robert, Prosser, Christine, Kelm, Sebastian, Sullivan, Amy H., Fox, David, Carr, Mark D., Henry, Alistair, Taylor, Richard, Meier, Beat H., Oschkinat, Hartmut, Lawson, Alastair D.
Publicado no PLoS Biol (2018)