Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response

Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).  This stress response results in expansion of the ER, upregulation of proteins involved in protein folding and degradation, and attenuation...

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Bibliografiska uppgifter
I publikationen:Wellcome Open Res
Huvudupphovsmän: Chalmers, Fiona, van Lith, Marcel, Sweeney, Bernadette, Cain, Katharine, Bulleid, Neil J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: F1000Research 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645705/
https://ncbi.nlm.nih.gov/pubmed/29062910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.11764.2
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