IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

All eukaryotic cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) by signaling an adaptive pathway termed the unfolded protein response (UPR). In yeast, a type-I ER transmembrane protein kinase, Ire1p, is the proximal sensor of unfolded proteins in the ER lumen...

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Autori principali: Lee, Kyungho, Tirasophon, Witoon, Shen, Xiaohua, Michalak, Marek, Prywes, Ron, Okada, Tetsuya, Yoshida, Hiderou, Mori, Kazutoshi, Kaufman, Randal J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2002
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC155339/
https://ncbi.nlm.nih.gov/pubmed/11850408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.964702
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