IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

All eukaryotic cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) by signaling an adaptive pathway termed the unfolded protein response (UPR). In yeast, a type-I ER transmembrane protein kinase, Ire1p, is the proximal sensor of unfolded proteins in the ER lumen...

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Detalhes bibliográficos
Main Authors: Lee, Kyungho, Tirasophon, Witoon, Shen, Xiaohua, Michalak, Marek, Prywes, Ron, Okada, Tetsuya, Yoshida, Hiderou, Mori, Kazutoshi, Kaufman, Randal J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155339/
https://ncbi.nlm.nih.gov/pubmed/11850408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.964702
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