Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)–Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 kHz after sedimentation, exploiting very fast spinn...

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Dettagli Bibliografici
Pubblicato in:PLoS Biol
Autori principali: Stöppler, Daniel, Macpherson, Alex, Smith-Penzel, Susanne, Basse, Nicolas, Lecomte, Fabien, Deboves, Hervé, Taylor, Richard D., Norman, Tim, Porter, John, Waters, Lorna C., Westwood, Marta, Cossins, Ben, Cain, Katharine, White, James, Griffin, Robert, Prosser, Christine, Kelm, Sebastian, Sullivan, Amy H., Fox, David, Carr, Mark D., Henry, Alistair, Taylor, Richard, Meier, Beat H., Oschkinat, Hartmut, Lawson, Alastair D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
Soggetti:
Methods and Resources
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983862/
https://ncbi.nlm.nih.gov/pubmed/29782488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006192
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