Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)–Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 kHz after sedimentation, exploiting very fast spinn...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Stöppler, Daniel, Macpherson, Alex, Smith-Penzel, Susanne, Basse, Nicolas, Lecomte, Fabien, Deboves, Hervé, Taylor, Richard D., Norman, Tim, Porter, John, Waters, Lorna C., Westwood, Marta, Cossins, Ben, Cain, Katharine, White, James, Griffin, Robert, Prosser, Christine, Kelm, Sebastian, Sullivan, Amy H., Fox, David, Carr, Mark D., Henry, Alistair, Taylor, Richard, Meier, Beat H., Oschkinat, Hartmut, Lawson, Alastair D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Methods and Resources
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983862/
https://ncbi.nlm.nih.gov/pubmed/29782488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006192
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