Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)–Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 kHz after sedimentation, exploiting very fast spinn...

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Veröffentlicht in:PLoS Biol
Hauptverfasser: Stöppler, Daniel, Macpherson, Alex, Smith-Penzel, Susanne, Basse, Nicolas, Lecomte, Fabien, Deboves, Hervé, Taylor, Richard D., Norman, Tim, Porter, John, Waters, Lorna C., Westwood, Marta, Cossins, Ben, Cain, Katharine, White, James, Griffin, Robert, Prosser, Christine, Kelm, Sebastian, Sullivan, Amy H., Fox, David, Carr, Mark D., Henry, Alistair, Taylor, Richard, Meier, Beat H., Oschkinat, Hartmut, Lawson, Alastair D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Methods and Resources
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983862/
https://ncbi.nlm.nih.gov/pubmed/29782488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006192
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