Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR

Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)–Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 kHz after sedimentation, exploiting very fast spinn...

詳細記述

保存先:
書誌詳細
出版年:PLoS Biol
主要な著者: Stöppler, Daniel, Macpherson, Alex, Smith-Penzel, Susanne, Basse, Nicolas, Lecomte, Fabien, Deboves, Hervé, Taylor, Richard D., Norman, Tim, Porter, John, Waters, Lorna C., Westwood, Marta, Cossins, Ben, Cain, Katharine, White, James, Griffin, Robert, Prosser, Christine, Kelm, Sebastian, Sullivan, Amy H., Fox, David, Carr, Mark D., Henry, Alistair, Taylor, Richard, Meier, Beat H., Oschkinat, Hartmut, Lawson, Alastair D.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2018
主題:
Methods and Resources
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983862/
https://ncbi.nlm.nih.gov/pubmed/29782488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006192
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