To be or not to be

Por Zhang, Zhe, Hessmann, Elisabeth
Publicado no eLife (2018)

Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?

Por Hessmann, Elisabeth, Johnsen, Steven A, Siveke, Jens T, Ellenrieder, Volker
Publicado no Gut (2017)

Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression

Por Hasselluhn, Marie C., Schmidt, Geske E., Ellenrieder, Volker, Johnsen, Steven A., Hessmann, Elisabeth
Publicado no Cell Death Dis (2019)

Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models

Por Goetze, Robert-Guenther, Buchholz, Soeren M., Patil, Shilpa, Petzold, Golo, Ellenrieder, Volker, Hessmann, Elisabeth, Neesse, Albrecht
Publicado no J Vis Exp (2018)

NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

Por Hessmann, Elisabeth, Zhang, Jin-San, Chen, Nai-Ming, Hasselluhn, Marie, Liou, Geou-Yarh, Storz, Peter, Ellenrieder, Volker, Billadeau, Daniel D., Koenig, Alexander
Publicado no Stem Cells Int (2016)

Preclinical Evaluation of 1,2-Diamino-4,5-Dibromobenzene in Genetically Engineered Mouse Models of Pancreatic Cancer

Por Goetze, Robert G., Buchholz, Soeren M., Ou, Ning, Zhang, Qinrong, Patil, Shilpa, Schirmer, Markus, Singh, Shiv K., Ellenrieder, Volker, Hessmann, Elisabeth, Lu, Qing-Bin, Neesse, Albrecht
Publicado no Cells (2019)

Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer

Por Buchholz, Soeren M., Goetze, Robert G., Singh, Shiv K., Ammer-Herrmenau, Christoph, Richards, Frances M., Jodrell, Duncan I., Buchholz, Malte, Michl, Patrick, Ellenrieder, Volker, Hessmann, Elisabeth, Neesse, Albrecht
Publicado no Cancers (Basel) (2020)

SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer

Por Ramu, Iswarya, Buchholz, Sören M., Patzak, Melanie S., Goetze, Robert G., Singh, Shiv K., Richards, Frances M., Jodrell, Duncan I., Sipos, Bence, Ströbel, Philipp, Ellenrieder, Volker, Hessmann, Elisabeth, Neesse, Albrecht
Publicado no EBioMedicine (2019)

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner

Por Mishra, Vivek Kumar, Wegwitz, Florian, Kosinsky, Robyn Laura, Sen, Madhobi, Baumgartner, Roland, Wulff, Tanja, Siveke, Jens T., Schildhaus, Hans-Ulrich, Najafova, Zeynab, Kari, Vijayalakshmi, Kohlhof, Hella, Hessmann, Elisabeth, Johnsen, Steven A.
Publicado no Nucleic Acids Res (2017)

Nuclear factor of activated T-cells, NFATC1, governs FLT3(ITD)-driven hematopoietic stem cell transformation and a poor prognosis in AML

Por Solovey, Maria, Wang, Ying, Michel, Christian, Metzeler, Klaus H., Herold, Tobias, Göthert, Joachim R., Ellenrieder, Volker, Hessmann, Elisabeth, Gattenlöhner, Stefan, Neubauer, Andreas, Pavlinic, Dinko, Benes, Vladimir, Rupp, Oliver, Burchert, Andreas
Publicado no J Hematol Oncol (2019)

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar–Ductal Transdifferentiation in the Pancreas

Por Chen, Nai-Ming, Singh, Garima, Koenig, Alexander, Liou, Geou-Yarh, Storz, Peter, Zhang, Jin-San, Regul, Lisanne, Nagarajan, Sankari, Kühnemuth, Benjamin, Johnsen, Steven A., Hebrok, Matthias, Siveke, Jens, Billadeau, Daniel D, Ellenrieder, Volker, Hessmann, Elisabeth
Publicado no Gastroenterology (2015)

Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling

Por Emons, Georg, Spitzner, Melanie, Reineke, Sebastian, Möller, Janneke, Auslander, Noam, Kramer, Frank, Hu, Yue, Beissbarth, Tim, Wolff, Hendrik A., Rave-Fränk, Margret, Heßmann, Elisabeth, Gaedcke, Jochen, Ghadimi, B. Michael, Johnsen, Steven A., Ried, Thomas, Grade, Marian
Publicado no Mol Cancer Res (2017)

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells

Por Sen, Madhobi, Wang, Xin, Hamdan, Feda H., Rapp, Jacobe, Eggert, Jessica, Kosinsky, Robyn Laura, Wegwitz, Florian, Kutschat, Ana Patricia, Younesi, Fereshteh S., Gaedcke, Jochen, Grade, Marian, Hessmann, Elisabeth, Papantonis, Argyris, Strӧbel, Philipp, Johnsen, Steven A.
Publicado no Clin Epigenetics (2019)

GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression

Por Baumgart, Sandra, Chen, Nai-ming, Zhang, Jin-San, Billadeau, Daniel D., Gaisina, Irina, Kozikowski, Alan P., Singh, Shiv, Fink, Daniel, Ströbel, Philipp, Klindt, Caroline, Zhang, Lizhi, Bamlet, William R., Koenig, Alexander, Hessmann, Elisabeth, Gress, Thomas, Ellenrieder, Volker, Neesse, Albrecht
Publicado no Mol Cancer Ther (2016)

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites

Por Patzak, Melanie S., Kari, Vijayalakshmi, Patil, Shilpa, Hamdan, Feda H., Goetze, Robert G., Brunner, Marius, Gaedcke, Jochen, Kitz, Julia, Jodrell, Duncan I., Richards, Frances M., Pilarsky, Christian, Gruetzmann, Robert, Rümmele, Petra, Knösel, Thomas, Hessmann, Elisabeth, Ellenrieder, Volker, Johnsen, Steven A., Neesse, Albrecht
Publicado no EBioMedicine (2019)

Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition

Por Russell, Ronan, Perkhofer, Lukas, Liebau, Stefan, Lin, Qiong, Lechel, André, Feld, Fenja M, Hessmann, Elisabeth, Gaedcke, Jochen, Güthle, Melanie, Zenke, Martin, Hartmann, Daniel, von Figura, Guido, Weissinger, Stephanie E, Rudolph, Karl-Lenhard, Möller, Peter, Lennerz, Jochen K, Seufferlein, Thomas, Wagner, Martin, Kleger, Alexander
Publicado no Nat Commun (2015)

Inflammation induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer initiation by Kras(G12D)

Por Baumgart, Sandra, Chen, Nai-ming, Siveke, Jens T., König, Alexander, Zhang, Jin-San, Singh, Shiv K., Wolf, Elmar, Bartkuhn, Marek, Esposito, Irene, Heßmann, Elisabeth, Reinecke, Johanna, Nikorowitsch, Julius, Brunner, Marius, Singh, Garima, Fernandez-Zapico, Martin E., Smyrk, Thomas, Bamlet, William R., Eilers, Martin, Neesse, Albrecht, Gress, Thomas M., Billadeau, Daniel D., Tuveson, David, Urrutia, Raul, Ellenrieder, Volker
Publicado em 2014

Antithetical NFATc1–Sox2 and p53–miR200 signaling networks govern pancreatic cancer cell plasticity

Por Singh, Shiv K, Chen, Nai-Ming, Hessmann, Elisabeth, Siveke, Jens, Lahmann, Marlen, Singh, Garima, Voelker, Nadine, Vogt, Sophia, Esposito, Irene, Schmidt, Ansgar, Brendel, Cornelia, Stiewe, Thorsten, Gaedcke, Jochen, Mernberger, Marco, Crawford, Howard C, Bamlet, William R, Zhang, Jin-San, Li, Xiao-Kun, Smyrk, Thomas C, Billadeau, Daniel D, Hebrok, Matthias, Neesse, Albrecht, Koenig, Alexander, Ellenrieder, Volker
Publicado no EMBO J (2015)

Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer

Por Gout, Johann, Perkhofer, Lukas, Morawe, Mareen, Arnold, Frank, Ihle, Michaela, Biber, Stephanie, Lange, Sebastian, Roger, Elodie, Kraus, Johann M, Stifter, Katja, Hahn, Stephan A, Zamperone, Andrea, Engleitner, Thomas, Müller, Martin, Walter, Karolin, Rodriguez-Aznar, Eva, Sainz Jr, Bruno, Hermann, Patrick C, Hessmann, Elisabeth, Müller, Sebastian, Azoitei, Ninel, Lechel, André, Liebau, Stefan, Wagner, Martin, Simeone, Diane M, Kestler, Hans A, Seufferlein, Thomas, Wiesmüller, Lisa, Rad, Roland, Frappart, Pierre-Olivier, Kleger, Alexander
Publicado no Gut (2021)

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

Por Mazur, Pawel K, Herner, Alexander, Mello, Stephano S, Wirth, Matthias, Hausmann, Simone, Sánchez-Rivera, Francisco J, Lofgren, Shane M, Kuschma, Timo, Hahn, Stephan A, Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noël, Peter B, Braren, Rickmer, Erkan, Mert, Kleeff, Jörg, Sipos, Bence, Sayles, Leanne C, Heikenwalder, Mathias, Heßmann, Elisabeth, Ellenrieder, Volker, Esposito, Irene, Jacks, Tyler, Bradner, James E, Khatri, Purvesh, Sweet-Cordero, E Alejandro, Attardi, Laura D, Schmid, Roland M, Schneider, Guenter, Sage, Julien, Siveke, Jens T
Publicado no Nat Med (2015)