Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a particularly dismal prognosis. Histone deacetylases (HDAC) are epigenetic modulators whose activity is frequently deregulated in various cancers including PDAC. In particular, class-I HDACs (HDAC 1, 2, 3 and 8) have been sh...

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Udgivet i:Nucleic Acids Res
Main Authors: Mishra, Vivek Kumar, Wegwitz, Florian, Kosinsky, Robyn Laura, Sen, Madhobi, Baumgartner, Roland, Wulff, Tanja, Siveke, Jens T., Schildhaus, Hans-Ulrich, Najafova, Zeynab, Kari, Vijayalakshmi, Kohlhof, Hella, Hessmann, Elisabeth, Johnsen, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499659/
https://ncbi.nlm.nih.gov/pubmed/28369619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx212
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