Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition

Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC indu...

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Publicado no:Nat Commun
Main Authors: Russell, Ronan, Perkhofer, Lukas, Liebau, Stefan, Lin, Qiong, Lechel, André, Feld, Fenja M, Hessmann, Elisabeth, Gaedcke, Jochen, Güthle, Melanie, Zenke, Martin, Hartmann, Daniel, von Figura, Guido, Weissinger, Stephanie E, Rudolph, Karl-Lenhard, Möller, Peter, Lennerz, Jochen K, Seufferlein, Thomas, Wagner, Martin, Kleger, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532798/
https://ncbi.nlm.nih.gov/pubmed/26220524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8677
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