Inflammation induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer initiation by Kras(G12D)

Cancer-associated inflammation is a molecular key feature in pancreatic ductal adenocarcinoma. Oncogenic KRAS in conjunction with persistent inflammation is known to accelerate carcinogenesis, although the underlying mechanisms remain poorly understood. Here we outline a novel pathway whereby the tr...

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Hauptverfasser: Baumgart, Sandra, Chen, Nai-ming, Siveke, Jens T., König, Alexander, Zhang, Jin-San, Singh, Shiv K., Wolf, Elmar, Bartkuhn, Marek, Esposito, Irene, Heßmann, Elisabeth, Reinecke, Johanna, Nikorowitsch, Julius, Brunner, Marius, Singh, Garima, Fernandez-Zapico, Martin E., Smyrk, Thomas, Bamlet, William R., Eilers, Martin, Neesse, Albrecht, Gress, Thomas M., Billadeau, Daniel D., Tuveson, David, Urrutia, Raul, Ellenrieder, Volker
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069603/
https://ncbi.nlm.nih.gov/pubmed/24694735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0593
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