Disruption of a Nuclear NFATc2 Protein Stabilization Loop Confers Breast and Pancreatic Cancer Growth Suppression by Zoledronic Acid

The aminobisphosphonate zoledronic acid has elicited significant attention due to its remarkable anti-tumoral activity, although its detailed mechanism of action remains unclear. Here, we demonstrate the existence of a nuclear GSK-3β-NFATc2 stabilization pathway that promotes breast and pancreatic c...

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Main Authors: Singh, Shiv K., Baumgart, Sandra, Singh, Garima, König, Alexander O., Reutlinger, Kristina, Hofbauer, Lorenz C., Barth, Peter, Gress, Thomas M., Lomberk, Gwen, Urrutia, Raul, Fernandez-Zapico, Martin E., Ellenrieder, Volker
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190684/
https://ncbi.nlm.nih.gov/pubmed/21628454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197533
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