Sequential Activation of NFAT and c-Myc Transcription Factors Mediates the TGF-β Switch from a Suppressor to a Promoter of Cancer Cell Proliferation

Transforming growth factor β (TGF-β) has a dual role in carcinogenesis, acting as a growth inhibitor in early tumor stages and a promoter of cell proliferation in advanced diseases. Although this cellular phenomenon is well established, the underlying molecular mechanisms remain elusive. Here, we re...

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Detalhes bibliográficos
Main Authors: Singh, Garima, Singh, Shiv K., König, Alexander, Reutlinger, Kristina, Nye, Monica D., Adhikary, Tillman, Eilers, Martin, Gress, Thomas M., Fernandez-Zapico, Martin E., Ellenrieder, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930723/
https://ncbi.nlm.nih.gov/pubmed/20516082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.100438
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