NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar–Ductal Transdifferentiation in the Pancreas

BACKGROUND & AIMS: Oncogenic Kras mutation is a defining genetic alteration in pancreatic ductal adenocarcinoma (PDAC), but is not sufficient to promote cancer formation on ist own. Secondary events, such as inflammation-induced signaling via the epidermal growth factor receptor (EGFR) and expre...

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Bibliografiske detaljer
Udgivet i:Gastroenterology
Main Authors: Chen, Nai-Ming, Singh, Garima, Koenig, Alexander, Liou, Geou-Yarh, Storz, Peter, Zhang, Jin-San, Regul, Lisanne, Nagarajan, Sankari, Kühnemuth, Benjamin, Johnsen, Steven A., Hebrok, Matthias, Siveke, Jens, Billadeau, Daniel D, Ellenrieder, Volker, Hessmann, Elisabeth
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409493/
https://ncbi.nlm.nih.gov/pubmed/25623042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.01.033
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