SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterised by extensive matrix deposition that has been implicated in impaired drug delivery and therapeutic resistance. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that regulates collagen deposition and is...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Ramu, Iswarya, Buchholz, Sören M., Patzak, Melanie S., Goetze, Robert G., Singh, Shiv K., Richards, Frances M., Jodrell, Duncan I., Sipos, Bence, Ströbel, Philipp, Ellenrieder, Volker, Hessmann, Elisabeth, Neesse, Albrecht
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838446/
https://ncbi.nlm.nih.gov/pubmed/31597597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.09.024
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