A short discussion about the SARS-CoV-2 mRNA-1273 vaccine

Por Oronsky, Bryan, Gruber, Harry E., Reiners, Wendy, Reid, Tony R.
Publicado no Int J Infect Dis (2021)

RETROVIRAL REPLICATING VECTORS IN CANCER

Por Logg, Christopher R., Robbins, Joan M., Jolly, Douglas J., Gruber, Harry E., Kasahara, Noriyuki
Publicado no Methods Enzymol (2012)

Blockade of Type I Interferon (IFN) Production by Retroviral Replicating Vectors and Reduced Tumor Cell Responses to IFN Likely Contribute To Tumor Selectivity

Por Lin, Amy H., Burrascano, Cindy, Pettersson, Par L., Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J.
Publicado em 2014

Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models

Por Yagiz, Kader, Huang, Tiffany T., Lopez Espinoza, Fernando, Mendoza, Daniel, Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Publicado no Neuro Oncol (2016)

Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro

Por Lin, Amy H., Twitty, Christopher G., Burnett, Ryan, Hofacre, Andrew, Mitchell, Leah A., Espinoza, Fernando Lopez, Gruber, Harry E., Jolly, Douglas J.
Publicado no Mol Ther Nucleic Acids (2017)

Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors (RRV) in a rodent brain tumor model

Por Yin, Dali, Zhai, Yuying, Gruber, Harry E., Ibanez, Carlos E., Robbins, Joan M., Kells, Adrian P., Kasahara, Noriyuki, Forsayeth, John, Jolly, Douglas J., Bankiewicz, Krystof S.
Publicado em 2013

Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model

Por Mitchell, Leah A., Lopez Espinoza, Fernando, Mendoza, Daniel, Kato, Yuki, Inagaki, Akihito, Hiraoka, Kei, Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Publicado no Neuro Oncol (2017)

Efficient Therapeutic Protein Expression Using Retroviral Replicating Vector with 2A Peptide in Cancer Models

Por Hofacre, Andrew, Yagiz, Kader, Mendoza, Daniel, Lopez Espinoza, Fernando, Munday, Anthony W., Burrascano, Cynthia, Singer, Oded, Gruber, Harry E., Jolly, Douglas J., Lin, Amy H.
Publicado no Hum Gene Ther (2018)

Radio-sensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector

Por Takahashi, Masamichi, Valdes, Gilmer, Hiraoka, Kei, Inagaki, Akihito, Kamijima, Shuichi, Micewicz, Ewa, Gruber, Harry E., Robbins, Joan M., Jolly, Douglas J., McBride, William H., Iwamoto, Keisuke S., Kasahara, Noriyuki
Publicado no Cancer Gene Ther (2014)

A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models

Por Yagiz, Kader, Rodriguez-Aguirre, Maria E., Lopez Espinoza, Fernando, Montellano, Tiffany T., Mendoza, Daniel, Mitchell, Leah A., Ibanez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Publicado no Mol Ther Oncolytics (2017)

Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids

Por Burnett, Ryan, Ibañez, Carlos E., Pettersson, Pär L., Chen, Ching-I, Parab, Shraddha, Huang, Tiffany, Robbins, Joan, Bankiewicz, Krystof, Aghi, Manish, Logg, Christopher, Kasahara, Noriyuki, Pertschuk, Dan, Gruber, Harry E., Jolly, Douglas J.
Publicado no Mol Ther Methods Clin Dev (2014)

Intravenous Administration of Retroviral Replicating Vector, Toca 511, Demonstrates Therapeutic Efficacy in Orthotopic Immune-Competent Mouse Glioma Model

Por Huang, Tiffany T., Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M., Lopez Espinoza, Fernando, Martin, Bryan, Ibañez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Pertschuk, Daniel, Jolly, Douglas J., Robbins, Joan M.
Publicado no Hum Gene Ther (2015)

ET-60 ENHANCED THERAPEUTIC EFFICACY OF PRODRUG ACTIVATOR GENE THERAPY WITH A NON-LYTIC RETROVIRAL REPLICATING VECTOR (TOCA 511) COMBINED WITH RADIATION THERAPY IN EXPERIMENTAL GLIO...

Por Takahashi, Masamichi, Valdes, Gilmer, Inagaki, Akihito, Kamijima, Shuichi, Hiraoka, Kei, Micewicz, Ewa, McBride, William H., Iwamoto, Keisuke S., Hermann, Kip, Collins, Sara, Tam, Quincy, Gruber, Harry E., Robbins, Joan M., Jolly, Douglas J., Kasahara, Noriyuki
Publicado em 2014

Retroviral replicating vector–mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity

Por Hiraoka, Kei, Inagaki, Akihito, Kato, Yuki, Huang, Tiffany T., Mitchell, Leah A., Kamijima, Shuichi, Takahashi, Masamichi, Matsumoto, Hiroshi, Hacke, Katrin, Kruse, Carol A., Ostertag, Derek, Robbins, Joan M., Gruber, Harry E., Jolly, Douglas J., Kasahara, Noriyuki
Publicado no Neuro Oncol (2017)

Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression

Por Perez, Omar D, Logg, Christopher R, Hiraoka, Kei, Diago, Oscar, Burnett, Ryan, Inagaki, Akihito, Jolson, Dawn, Amundson, Karin, Buckley, Taylor, Lohse, Dan, Lin, Amy, Burrascano, Cindy, Ibanez, Carlos, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J
Publicado em 2012

PD-L1 checkpoint blockade delivered by retroviral replicating vector confers anti-tumor efficacy in murine tumor models

Por Mitchell, Leah A., Yagiz, Kader, Hofacre, Andrew, Viaud, Sophie, Munday, Anthony W., Espinoza, Fernando Lopez, Mendoza, Daniel, Rodriguez-Aguirre, Maria E., Bergqvist, Simon, Haghighi, Ali, Miner, Marin V., Accomando, William P., Burrascano, Cynthia, Gammon, Dawn, Gruber, Harry E., Jolly, Douglas J., Lin, Amy H.
Publicado no Oncotarget (2019)

Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector

Por Ostertag, Derek, Amundson, Karin K., Lopez Espinoza, Fernando, Martin, Bryan, Buckley, Taylor, da Silva, Ana Paula Galvão, Lin, Amy H., Valenta, David T., Perez, Omar D., Ibañez, Carlos E., Chen, Ching-I, Pettersson, Pär L., Burnett, Ryan, Daublebsky, Veronika, Hlavaty, Juraj, Gunzburg, Walter, Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Publicado em 2012

Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC

Por Cloughesy, Timothy F, Landolfi, Joseph, Vogelbaum, Michael A, Ostertag, Derek, Elder, James B, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh, Piccioni, David, Accomando, William, Diago, Oscar R, Hogan, Daniel J, Gammon, Dawn, Kasahara, Noriyuki, Kheoh, Thian, Jolly, Douglas J, Gruber, Harry E, Das, Asha, Walbert, Tobias
Publicado no Neuro Oncol (2018)

Phase 1 Trial of Vocimagene Amiretrorepvec and 5-Fluorocytosine for Recurrent High Grade Glioma

Por Cloughesy, Timothy F., Landolfi, Joseph, Hogan, Daniel J, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Elder, J Bradley, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh Leia, Piccioni, David, Walbert, Tobias, Chu, Alice, Das, Asha, Diago, Oscar R, Gammon, Dawn, Gruber, Harry E, Hanna, Michelle, Jolly, Douglas J, Kasahara, Noriyuki, McCarthy, David, Mitchell, Leah, Ostertag, Derek, Robbins, Joan M, Rodriguez-Aguirre, Maria, Vogelbaum, Michael A
Publicado no Sci Transl Med (2016)