Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models

BACKGROUND: Toca 511, a gamma retroviral replicating vector encoding cytosine deaminase, used in combination with 5-fluorocytosine (5-FC) kills tumor by local production of 5-fluorouracil (5-FU), inducing local and systemic immunotherapeutic response resulting in long-term survival after cessation o...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Yagiz, Kader, Huang, Tiffany T., Lopez Espinoza, Fernando, Mendoza, Daniel, Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Basic and Translational Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035524/
https://ncbi.nlm.nih.gov/pubmed/27166379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now089
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