Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC

BACKGROUND: Vocimagene amiretrorepvec (Toca 511) is an investigational gamma-retroviral replicating vector encoding cytosine deaminase that, when used in combination with extended-release 5-fluorocytosine (Toca FC), results preclinically in local production of 5-fluorouracil, depletion of immune-sup...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Cloughesy, Timothy F, Landolfi, Joseph, Vogelbaum, Michael A, Ostertag, Derek, Elder, James B, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh, Piccioni, David, Accomando, William, Diago, Oscar R, Hogan, Daniel J, Gammon, Dawn, Kasahara, Noriyuki, Kheoh, Thian, Jolly, Douglas J, Gruber, Harry E, Das, Asha, Walbert, Tobias
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Clinical Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120351/
https://ncbi.nlm.nih.gov/pubmed/29762717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy075
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