Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC

BACKGROUND: Vocimagene amiretrorepvec (Toca 511) is an investigational gamma-retroviral replicating vector encoding cytosine deaminase that, when used in combination with extended-release 5-fluorocytosine (Toca FC), results preclinically in local production of 5-fluorouracil, depletion of immune-sup...

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Опубликовано в: :Neuro Oncol
Главные авторы: Cloughesy, Timothy F, Landolfi, Joseph, Vogelbaum, Michael A, Ostertag, Derek, Elder, James B, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh, Piccioni, David, Accomando, William, Diago, Oscar R, Hogan, Daniel J, Gammon, Dawn, Kasahara, Noriyuki, Kheoh, Thian, Jolly, Douglas J, Gruber, Harry E, Das, Asha, Walbert, Tobias
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
Clinical Investigations
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120351/
https://ncbi.nlm.nih.gov/pubmed/29762717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy075
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