Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids

Toca 511 is a novel retroviral replicating vector, encoding a modified yeast cytosine deaminase, administered to recurrent high grade glioma patients in Phase 1 trials by stereotactic, transcranial injection into the tumor or into the walls of the resection cavity. A key issue, with little published...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther Methods Clin Dev
Auteurs principaux: Burnett, Ryan, Ibañez, Carlos E., Pettersson, Pär L., Chen, Ching-I, Parab, Shraddha, Huang, Tiffany, Robbins, Joan, Bankiewicz, Krystof, Aghi, Manish, Logg, Christopher, Kasahara, Noriyuki, Pertschuk, Dan, Gruber, Harry E., Jolly, Douglas J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362351/
https://ncbi.nlm.nih.gov/pubmed/26015967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.24
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