Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector

Patients with the most common and aggressive form of high-grade glioma, glioblastoma multiforme, have poor prognosis and few treatment options. In 2 immunocompetent mouse brain tumor models (CT26-BALB/c and Tu-2449-B6C3F1), we showed that a nonlytic retroviral replicating vector (Toca 511) stably de...

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Detalhes bibliográficos
Main Authors: Ostertag, Derek, Amundson, Karin K., Lopez Espinoza, Fernando, Martin, Bryan, Buckley, Taylor, da Silva, Ana Paula Galvão, Lin, Amy H., Valenta, David T., Perez, Omar D., Ibañez, Carlos E., Chen, Ching-I, Pettersson, Pär L., Burnett, Ryan, Daublebsky, Veronika, Hlavaty, Juraj, Gunzburg, Walter, Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266384/
https://ncbi.nlm.nih.gov/pubmed/22070930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor199
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