ET-60 ENHANCED THERAPEUTIC EFFICACY OF PRODRUG ACTIVATOR GENE THERAPY WITH A NON-LYTIC RETROVIRAL REPLICATING VECTOR (TOCA 511) COMBINED WITH RADIATION THERAPY IN EXPERIMENTAL GLIOMA

A tumor-selective non-lytic retroviral replicating vector (RRV), Toca 511 (vocimagene amiretrorepvec), is being investigated in clinical trials in patients with recurrent high grade glioma (rHGG) (www.clinicaltrials.gov NCT01156584, NCT01470794, NCT01985256). Toca 511 encodes a modified yeast cytosi...

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Main Authors: Takahashi, Masamichi, Valdes, Gilmer, Inagaki, Akihito, Kamijima, Shuichi, Hiraoka, Kei, Micewicz, Ewa, McBride, William H., Iwamoto, Keisuke S., Hermann, Kip, Collins, Sara, Tam, Quincy, Gruber, Harry E., Robbins, Joan M., Jolly, Douglas J., Kasahara, Noriyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218156/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.57
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