Blockade of Type I Interferon (IFN) Production by Retroviral Replicating Vectors and Reduced Tumor Cell Responses to IFN Likely Contribute To Tumor Selectivity

We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host cells, and we show that RR...

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Bibliografische gegevens
Hoofdauteurs: Lin, Amy H., Burrascano, Cindy, Pettersson, Par L., Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2014
Onderwerpen:
Gene Delivery
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136332/
https://ncbi.nlm.nih.gov/pubmed/24965455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02300-13
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