Blockade of Type I Interferon (IFN) Production by Retroviral Replicating Vectors and Reduced Tumor Cell Responses to IFN Likely Contribute To Tumor Selectivity

We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host cells, and we show that RR...

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Detalhes bibliográficos
Main Authors: Lin, Amy H., Burrascano, Cindy, Pettersson, Par L., Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136332/
https://ncbi.nlm.nih.gov/pubmed/24965455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02300-13
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