Intracellular traffic and neurodegenerative disorders

Por St.George-Hyslop, Peter H., Mobley, William C.
Publicado em 2009

Structural and Chemical Biology of Presenilin Complexes

Por Johnson, Douglas S., Li, Yue-Ming, Pettersson, Martin, St George-Hyslop, Peter H.
Publicado no Cold Spring Harb Perspect Med (2017)

Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid β(42) from Isolated Intact Nerve Terminals

Por Kim, Soong Ho, Fraser, Paul E., Westaway, David, St. George-Hyslop, Peter H., Ehrlich, Michelle E., Gandy, Sam
Publicado em 2010

Structural biology of presenilin 1 complexes

Por Li, Yi, Bohm, Christopher, Dodd, Roger, Chen, Fusheng, Qamar, Seema, Schmitt-Ulms, Gerold, Fraser, Paul E, St George-Hyslop, Peter H
Publicado no Mol Neurodegener (2014)

The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

Por Brautigam, Hannah, Steele, John W, Westaway, David, Fraser, Paul E, George-Hyslop, Peter H St, Gandy, Sam, Hof, Patrick R, Dickstein, Dara L
Publicado em 2012

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

Por Schwarzman, Alexander L., Singh, Nandita, Tsiper, Maria, Gregori, Luisa, Dranovsky, Alex, Vitek, Michael P., Glabe, Charles G., St. George-Hyslop, Peter H., Goldgaber, Dmitry
Publicado em 1999

Identification of Novel Loci for Alzheimer Disease and Replication of CLU, PICALM, and BIN1 in Caribbean Hispanic Individuals

Por Lee, Joseph H., Cheng, Rong, Barral, Sandra, Reitz, Christiane, Medrano, Martin, Lantigua, Rafael, Jiménez-Velazquez, Ivonne Z., Rogaeva, Ekaterina, St. George-Hyslop, Peter H., Mayeux, Richard
Publicado em 2010

SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis

Por Orlacchio, Antonio, Babalini, Carla, Borreca, Antonella, Patrono, Clarice, Massa, Roberto, Basaran, Sarenur, Munhoz, Renato P., Rogaeva, Ekaterina A., St George-Hyslop, Peter H., Bernardi, Giorgio, Kawarai, Toshitaka
Publicado em 2010

Association of Distinct Variants in SORL1 With Cerebrovascular and Neurodegenerative Changes Related to Alzheimer Disease

Por Cuenco, Karen T., Lunetta, Kathryn L., Baldwin, Clinton T., McKee, Ann C., Guo, Jianping, Cupples, L. Adrienne, Green, Robert C., George-Hyslop, Peter H. St., Chui, Helena, DeCarli, Charles, Farrer, Lindsay A.
Publicado em 2008

Early Fear Memory Defects Are Associated with Altered Synaptic Plasticity and Molecular Architecture in the TgCRND8 Alzheimer's Disease Mouse Model

Por Steele, John W., Brautigam, Hannah, Short, Jennifer A., Sowa, Allison, Shi, Mengxi, Yadav, Aniruddha, Weaver, Christina M., Westaway, David, Fraser, Paul E., St George-Hyslop, Peter H., Gandy, Sam, Hof, Patrick R., Dickstein, Dara L.
Publicado no J Comp Neurol (2014)

ALS5/SPG11/ KIAA1840 mutations cause autosomal recessive axonal Charcot–Marie–Tooth disease

Por Montecchiani, Celeste, Pedace, Lucia, Lo Giudice, Temistocle, Casella, Antonella, Mearini, Marzia, Gaudiello, Fabrizio, Pedroso, José L., Terracciano, Chiara, Caltagirone, Carlo, Massa, Roberto, St George-Hyslop, Peter H., Barsottini, Orlando G. P., Kawarai, Toshitaka, Orlacchio, Antonio
Publicado no Brain (2016)

TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

Por Thornton, Peter, Sevalle, Jean, Deery, Michael J, Fraser, Graham, Zhou, Ye, Ståhl, Sara, Franssen, Elske H, Dodd, Roger B, Qamar, Seema, Gomez Perez‐Nievas, Beatriz, Nicol, Louise SC, Eketjäll, Susanna, Revell, Jefferson, Jones, Clare, Billinton, Andrew, St George‐Hyslop, Peter H, Chessell, Iain, Crowther, Damian C
Publicado no EMBO Mol Med (2017)

Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes

Por Li, Yi, Lu, Stephen Hsueh-Jeng, Tsai, Ching-Ju, Bohm, Christopher, Qamar, Seema, Dodd, Roger B., Meadows, William, Jeon, Amy, McLeod, Adam, Chen, Fusheng, Arimon, Muriel, Berezovska, Oksana, Hyman, Bradley T., Tomita, Taisuke, Iwatsubo, Takeshi, Johnson, Christopher M., Farrer, Lindsay A., Schmitt-Ulms, Gerold, Fraser, Paul E., St George-Hyslop, Peter H.
Publicado em 2014

Assessment of amyloid β-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases

Por Tanzi, Rudolph E., Vaula, Giovanna, Romano, Donna M., Mortilla, Marzia, Huang, Tricia L., Tupler, Rossella G., Wasco, Wilma, Hyman, Bradley T., Haines, Jonathan L., Jenkins, Barbara J., Kalaitsidaki, Marianna, Warren, Andrew C., McInnis, Melvin C., Antonarakis, Stylianos E., Karlinsky, Harry, Percy, Maire E., Connor, Linda, Growdon, John, Crapper-McIachlan, Donald R., Gusella, James F., George-Hyslop, Peter H. St
Publicado em 1992

Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease

Por Reitz, Christiane, Cheng, Rong, Rogaeva, Ekaterina, Lee, Joseph H., Tokuhiro, Shinya, Zou, Fanggeng, Bettens, Karolien, Sleegers, Kristel, Tan, Eng King, Kimura, Ryo, Shibata, Nobuto, Arai, Heii, Kamboh, M. Ilyas, Prince, Jonathan A., Maier, Wolfgang, Riemenschneider, Matthias, Owen, Michael, Harold, Denise, Hollingworth, Paul, Cellini, Elena, Sorbi, Sandro, Nacmias, Benedetta, Takeda, Masatoshi, Pericak-Vance, Margaret A., Haines, Jonathan L., Younkin, Steven, Williams, Julie, van Broeckhoven, Christine, Farrer, Lindsay A., St George–Hyslop, Peter H., Mayeux, Richard
Publicado em 2011

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model

Por Steele, John W., Lachenmayer, M. Lenard, Ju, Shulin, Stock, Aryeh, Liken, Jessica, Kim, Soong Ho, Delgado, Luz M., Alfaro, Iván E, Bernales, Sebastian, Verdile, Giuseppe, Bharadwaj, Prashant, Gupta, Veer, Barr, Renae, Friss, Amy, Dolios, Georgia, Wang, Rong, Ringe, Dagmar, Fraser, Paul, Westaway, David, St George-Hyslop, Peter H., Szabo, Paul, Relkin, Norman R., Buxbaum, Joseph D., Glabe, Charles G., Protter, Andrew A., Martins, Ralph N., Ehrlich, Michelle E., Petsko, Gregory A., Yue, Zhenyu, Gandy, Sam
Publicado em 2012

Transethnic genome-wide scan identifies novel Alzheimer disease loci

Por Jun, Gyungah R., Chung, Jaeyoon, Mez, Jesse, Barber, Robert, Beecham, Gary W., Bennett, David A., Buxbaum, Joseph D., Byrd, Goldie S., Carrasquillo, Minerva M., Crane, Paul K., Cruchaga, Carlos, De Jager, Philip, Ertekin-Taner, Nilufer, Evans, Denis, Fallin, M. Danielle, Foroud, Tatiana M., Friedland, Robert P., Goate, Alison M., Graff-Radford, Neill R., Hendrie, Hugh, Hall, Kathleen S., Hamilton-Nelson, Kara L., Inzelberg, Rivka, Kamboh, M. Ilyas, Kauwe, John SK, Kukull, Walter A., Kunkle, Brian W., Kuwano, Ryozo, Larson, Eric B., Logue, Mark W., Manly, Jennifer J., Martin, Eden R., Montine, Thomas J., Mukherjee, Shubhabrata, Naj, Adam, Reiman, Eric M., Reitz, Christiane, Sherva, Richard, George-Hyslop, Peter H., Thornton, Timothy, Younkin, Steven G., Vardarajan, Badri N., Wang, Li-San, Wendlund, Jens R., Winslow, Ashley R., Haines, Jonathan, Mayeux, Richard, Pericak-Vance, Margaret A., Schellenberg, Gerard, Lunetta, Kathryn L., Farrer, Lindsay A.
Publicado no Alzheimers Dement (2017)

A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN

Por Jun, Gyungah, Ibrahim-Verbaas, Carla A., Vronskaya, Maria, Lambert, Jean-Charles, Chung, Jaeyoon, Naj, Adam C., Kunkle, Brian W., Wang, Li-San, Bis, Joshua C., Bellenguez, Céline, Harold, Denise, Lunetta, Kathryn L., Destefano, Anita L., Grenier-Boley, Benjamin, Sims, Rebecca, Beecham, Gary W., Smith, Albert V., Chouraki, Vincent, Hamilton-Nelson, Kara L., Ikram, M. Arfan, Fievet, Nathalie, Denning, Nicola, Martin, Eden R., Schmidt, Helena, Kamatani, Yochiro, Dunstan, Melanie L, Valladares, Otto, Laza, Agustin Ruiz, Zelenika, Diana, Ramirez, Alfredo, Foroud, Tatiana M., Choi, Seung-Hoan, Boland, Anne, Becker, Tim, Kukull, Walter A., van der Lee, Sven J., Pasquier, Florence, Cruchaga, Carlos, Beekly, Duane, Fitzpatrick, Annette L., Hanon, Oliver, Gill, Michael, Barber, Robert, Gudnason, Vilmundur, Campion, Dominique, Love, Seth, Bennett, David A., Amin, Najaf, Berr, Claudine, Tsolaki, Magda, Buxbaum, Joseph D., Lopez, Oscar L., Deramecourt, Vincent, Fox, Nick C, Cantwell, Laura B., Tárraga, Lluis, Dufouil, Carole, Hardy, John, Crane, Paul K., Eiriksdottir, Gudny, Hannequin, Didier, Clarke, Robert, Evans, Denis, Mosley, Thomas H., Letenneur, Luc, Brayne, Carol, Maier, Wolfgang, De Jager, Philip, Emilsson, Valur, Dartigues, Jean-François, Hampel, Harald, Kamboh, M. Ilyas, de Bruijn, Renee F.A.G., Tzourio, Christophe, Pastor, Pau, Larson, Eric B., Rotter, Jerome I., O’Donovan, Michael C, Montine, Thomas J., Nalls, Michael A., Mead, Simon, Reiman, Eric M., Jonsson, Palmi V., Holmes, Clive, St George-Hyslop, Peter H., Boada, Mercè, Passmore, Peter, Wendland, Jens R., Schmidt, Reinhold, Morgan, Kevin, Winslow, Ashley R., Powell, John F, Carasquillo, Minerva, Younkin, Steven G., Jakobsdóttir, Jóhanna, Kauwe, John SK, Wilhelmsen, Kirk C., Rujescu, Dan, Nöthen, Markus M, Hofman, Albert, Jones, Lesley, Haines, Jonathan L., Psaty, Bruce M., Van Broeckhoven, Christine, Holmans, Peter, Launer, Lenore J., Mayeux, Richard, Lathrop, Mark, Goate, Alison M., Escott-Price, Valentina, Seshadri, Sudha, Pericak-Vance, Margaret A., Amouyel, Philippe, Williams, Julie, van Duijn, Cornelia M., Schellenberg, Gerard D., Farrer, Lindsay A.
Publicado no Mol Psychiatry (2015)