Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model

Latrepirdine (Dimebon™) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to moderate Alzheimer’s disease, with a dramatically positive outcome in a Russian clinical trial that was unconfirmed in a replication trial in the United States. We sought...

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Detalhes bibliográficos
Main Authors: Steele, John W., Lachenmayer, M. Lenard, Ju, Shulin, Stock, Aryeh, Liken, Jessica, Kim, Soong Ho, Delgado, Luz M., Alfaro, Iván E, Bernales, Sebastian, Verdile, Giuseppe, Bharadwaj, Prashant, Gupta, Veer, Barr, Renae, Friss, Amy, Dolios, Georgia, Wang, Rong, Ringe, Dagmar, Fraser, Paul, Westaway, David, St George-Hyslop, Peter H., Szabo, Paul, Relkin, Norman R., Buxbaum, Joseph D., Glabe, Charles G., Protter, Andrew A., Martins, Ralph N., Ehrlich, Michelle E., Petsko, Gregory A., Yue, Zhenyu, Gandy, Sam
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625697/
https://ncbi.nlm.nih.gov/pubmed/22850627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2012.106
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